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The aim of this study is to improve the biological and mechanical properties of zirconia-based PICN (polymer-infiltrated-ceramic-network) materials by fabrication an enamel-like structure on its surface. Fluorapatite (FA) arrays were fabricated on zirconia discs by hydrothermal treatment. After polymer infiltration, an enamel-like structure was obtained on zirconia-based PICN materials. Effects of hydrothermal treatment conditions on the FA arrays were investigated by XRD, FTIR and SEM. Human gingival fibroblast cells (HGFs) and Escheric