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Background To investigate the association between involuntary weight loss (IWL) and late-life depression (LLD) in a population-based cohort study. Methods Data (N=6945) obtained from the 2008 baseline and 2011 follow-up assessments of the Living Profiles of Older People Survey in Korea were used. Changed body weight between the 2008 and 2011 was classified into stable weight ( less then -5% ∼ less then +5%), lightweight loss (≥ -5% ∼ less then -10%), moderate weight loss (≥ -10%), lightweight gain (+≥5 ∼ less then +10%), and moderate we