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Knockdown ofYTHDC2 considerably promoted the proliferation price of ESCC cells by affecting several cancer-related signaling pathways. Our outcomes suggested that rs2416282 contributed to ESCC risk by regulatingYTHDC2 phrase. This research provided us a very important insight into the functions of genetic variants in m6A adjustment genes for ESCC susceptibility and could subscribe to the avoidance with this illness in the foreseeable future. © The Author(s) 2020. Published by Oxford Universit