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Herein, glucose oxidase (GOx) functionalized ancient pigment nanosheets (SrCuSi4 O10 , SC) for programmable near-infrared II (NIR-II) photothermal-enhanced hunger primed CDT is created. The SC nanosheets (SC NSs) tend to be easily exfoliated from SC volume suspension system in liquid and subsequently functionalized with GOx to form the nanocatalyst (denoted as SC@G NSs). Upon laser irradiation, the photothermal effectation of SC NSs can enhance the catalytic task of GOx for NIR-II photothermal-enhan