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Medetomidine, methadone and fentanyl combinations are not recommended for use in patients where an increase in IOP or decrease in PS is undesirable. Medetomidine, methadone and fentanyl combinations are not recommended for use in patients where an increase in IOP or decrease in PS is undesirable.Coronavirus disease 2019 (COVID-19) infection can involve many organs, such as central nervous system, including in relapse. We describe the case of a 64-year-old woman with microbiologically confirmed COVID-19-induced respiratory distress whose t