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This study investigates age-related variations in mental performance intracellular microenvironment by comparing the evident diffusion coefficients (ADC) and apparent transverse relaxation time constants (T2) of 5 neurochemicals (i.e., total N-acetyl-aspartate, complete creatine, complete choline, glutamate, and myo-inositol) between young and older grownups. Thirty-two youthful healthy adults (18-22 years) and 26 older healthier adults (70-83 years) had been recruited. Three br