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Aging may act by the increased susceptibility to infections, by immunological modifications or hormonal disturbances. The role of the cellular infiltration around the joints remains a crucial question. Only a handful of studies described this infiltration. Finally, this review reveals the gaps in available data and suggests new leads and in-depth studies for further research on PMR pathophysiology. RELATIONSHIP BETWEEN MALIGNANCIES AND MUSCULOSKELETAL DISEASES Oncorheumatology is the meeting point of tumor formation and rhe