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Baseline characteristics and the safety profile were comparable between the groups. However, fatigue (22.8% versus 13.0%) and decreased appetite (8.8% versus 1.2%) were more frequent in elderly patients. Younger versus elderly patients equally benefited in terms of objective response rate (36% versus 48%), median progression-free survival (5.6 versus 5.5months; hazard ratio [HR]=1.03; p=0.81) and OS (10.6 versus 10.2months; HR=0.89; p=0.4). In addition, the median treatment duration (5 versus 4 cycles), relative dose intensity (
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