What Causes Trucking Accidents? Trucks constitute a tiny portion of the vehicles on road however, they are a risk and can cause severe injury or death. Accidents involving large vehicles can be caused by drivers who are distracted or do not pay attention to their blind areas. Accidents in the trucking industry can also be caused by driver fatigue. These drivers work long hours without taking breaks in order to fulfill their quotas. Driver Error Driver errors are the leading cause of trucking accidents and it's a serious problem. Driver errors