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The radiolabeling, including purification, was performed in 30 min [18F]AlF-NOTA-HL exhibited good in vitro stability. PET studies in normal mice revealed high specific accumulation of activity in the liver. Conclusion NOTA-HL could be labeled rapidly and efficiently with aqueous 18F using AlF method. [18F]AlF-NOTA-HL would provide another efficient approach for PET imaging of ASGPR.Ginger (Zingiber officinale Roscoe) is a valuable culinary and medicinal plant. The compound 6-gingerol is the main gingerol in ginger rhizomes and it posses