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5 vs. 2.7 per 100 PY; P0.0001), decompensation (5.5 vs. 4.0 per 100 PY; P=0.002), and HCC (0.9 vs. 0.3 per 100 PY; P0.0001). After adjusting for confounders,male sex was associated with ahigherrisk of death or transplantation (adjusted hazard ratio, 1.80; 95% CI, 1.01-3.19; P=0.046), and liver-related death or transplantation (subhazard ratio, 2.17; 95% CI, 1.15-4.08; P=0.02).A sensitivity analysis that defined ursodeoxycholic acid response as normalization of alkaline phosphatase and total bilirubin revealed similar findings. In patients with PBC a
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