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f cell proliferation, migration and invasion by targeting NRP2. Circ_CHFR promoted the proliferation, invasion and migration of PDGF-BB-induced HVSMCs via miR-149-5p/NRP2 axis, providing a new insight into the pathogenesis of AS and a potential therapeutic target for AS treatment. Hypercholesterolemia is a leading cause of cardiovascular morbidity and mortality. Accordingly, efforts to lower apolipoprotein B-containing lipoproteins in plasma are the centerpiece of strategies for cardiovascular prevention and treatment in primary and sec