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This systematic review and meta-analysis was performed to summarize the long-term (more than 6months) effect of growth hormone (GH) replacement therapy (GHRT) on glucose metabolism among adults growth hormone deficiency (AGHD) patients. We searched MEDLINE, EMBASE and the Cochrane Library databases from inception till March 2020 for relevant studies evaluating the effect of GHRT on glucose metabolism in AGHD patients. Results were stratified into two periods (6-12months and more than12 months) according to the length of follow-up. Thirty-three studies inclu
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