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Hypercholesterolemia is a metabolic disorder associated with atherosclerosis. This study aimed to investigate the effects of omega-3 and/or coenzyme Q10 (CoQ1 on hypercholesterolemia-induced atherosclerosis. Rats were divided into five groups; (1) served as the negative control, (2) served as hypercholesterolemic (HC) control, (3) HC-rats administrated omega-3 orally, (4) HC-rats administrated CoQ10 orally, and (5) HC-rats administered the combination treatment of both omega-3 and CoQ10. Lipid profile was assayed and cardiovascular r