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OBJECTIVE To evaluate novel surgical variations of laparoscopic ovarian drilling (LOD) and compare with standard bilateral LOD. DATA SOURCES Electronic databases were searched including Cochrane database, CENTRAL, Ovid MEDLINE, Embase, PsycINFO, PubMed, Virtual Health Library, OpenSIGLE, ClinicalTrials.gov, ISRCTN, The Chinese Clinical Trial Register in February 2019. METHODS OF STUDY SELECTION Randomized controlled trials (RCTs) evaluating LOD for patients with clomiphene-resistant polycystic ovary syndrome (PCOS) and infertility, rep