https://www.selleckchem.com/pr....oducts/Floxuridine.h
The novel HLA-C*040101102 allele differs from HLA-C*04010101 by G → A nucleotide change at gDNA 2591.Compared with HLA-B*46010101, the alleles HLA-B*4680 and HLA-B*4681 each show one nucleotide substitution, respectively.The methylase METTL3 is the writer enzyme of the N6 -methyladenosine (m6 A) modification of RNA. Using a structure-based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM, while its enantiomer is 100 times less active. We observed a dose-dependent reduction in th
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