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Successful application of the developed methods was carried out for determination of the studied drugs in human spiked plasma and in Logimax® tablets. The developed RP-HPLC and HPTLC methods can be further applied for quality control testing of the studied drugs. RP-HPLC and HPTLC methods for determination of FEL, MET and their major metabolites. The developed methods were successfully applied for determination of FEL and MET in Logimax® tablets. RP-HPLC and HPTLC methods for determination of FEL, MET and their major metabolites. The