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The social isolation imposed by COVID-19 pandemic can have a major impact on the mental health of dementia patients and their caregivers. We aim to evaluate the neurological decline of patients with dementia and the caregivers' burden during the pandemic. We performed a cross-sectional study. Caregivers of dementia patients following in the outpatient clinic were included. A structured telephone interview composed of the Neuropsychiatric Inventory Questionnaire (NPI-Q), Zarit Burden Interview (ZBI), Beck Depression (BDI) and Anxiety (BA