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How a VC Can Affect Your Heart PVCs are common and can be experienced by many people without causing any problems. If they occur often, PVCs may weaken your heart and increase the risk of heart failure. The rhythm of your heart is controlled by a bundle of nerve fibers situated in the upper right-hand part of your heart. This is known as the sinoatrial node, or SA. Electrical signals travel from this node to the lower heart chambers, or ventricles. Causes PVCs are caused by the electrical impulse that normally in