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apoptosis rate of experimental group and SphK1 activator group at ACR 2.5 mmol/L was significantly different (P less then 0.05) ; compared with experimental group, the apoptosis rate of SphK1 activator group at ACR 2.5 mmol/L was lower, the difference was statistically significant (P less then 0.05) . Conclusion The SphK1 excessive expression plays the protective function to the nerve cell damage caused by acrylamide.Objective To explore the method of noninvasive hemodynamic monitoring system (NICaS) in monitoring the hemodynamics of p