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The positive outcome of the present situation proposes thinking about this method for patients with RASopathies and mind tumors with hyperactivated MTOR signaling.Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (BCR) gene on chromosome 9 and ABL proto-oncogene 1 (ABL1) gene on chromosome 22. The fusion gene, BCR-ABL1, is a constitutively active tyrosine kinase which encourages development of leukemia. With respect to the break