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The SAMe-TT R score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores 2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT R scores 2 than to patients with lower scores. We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in