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the test cohort was 4 out of 5. Conclusions Preoperative CT based deep-learning model provides a promising novel method for predicting CR-POPF occurrences after PD, especially at intermediate FRS risk level. This has a potential to be integrated into radiologic reporting system or incorporated into surgical planning software to accommodate the preferences of surgeons to optimize preoperative strategies, intraoperative decision-making, and even postoperative care.Rationale Currently, for locoregionally advanced nasopharyngeal carcinoma (LA-NPC), there is no