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In conclusion, IBS-D patients following a controlled long-term LFD experienced improved symptom profiles and decreased inflammatory markers linked to FAs. Lipidomic data may be insightful for unravelling the molecular mechanisms associated with IBS-D pathophysiology.Production of artificial lightweight aggregate (LWA) from industrial by-products or abundant volcanic mud is a promising solution to prevent damaging the environment due to the mining of natural aggregate. However, improvements are still needed in order to control the high w