https://www.selleckchem.com/pr....oducts/srt2104-gsk22
Patients treated with cancer chemotherapeutics frequently report chemotherapy-induced peripheral neuropathy (CIPN), changes in mood (depression and anxiety) and functional impairments. Rodent models of CIPN elicit limited alterations in functional behaviors, which pose challenges in developing preclinical models of chemotherapy-induced behavioral depression. The study examined the consequences of chemotherapy-induced mechanical hypersensitivity (paclitaxel 32 or 64 mg/kg, cumulative; oxaliplatin 30 mg/kg, cumulative) on behav
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