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Heart problems (CVD) in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTI) has not been examined. Here we make an effort to examine this. SETTING Retrospective cohort design study TECHNIQUES We used the IBM®MarketScan® databases for U.S. commercially insured and Medicaid covered grownups to spot PLWH newly initiated on ART between Jan 1, 2008 and Dec 30, 2015. Significant adverse cardiac event (MACE), a composite of acute MI, ischemic stroke, coronary artery bypas