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To what extent do characteristics of germline genome editing (GGE) determine whether the general public supports permitting the clinical use of GGE? The risk that GGE would cause congenital abnormalities had the largest effect on support for allowing GGE, followed by effectiveness of GGE, while costs, the type of application (disease or enhancement) and the effect on child well-being had moderate effects. Scientific progress on GGE has increased the urgency of resolving whether and when clinical application of GGE may be ethically acceptab