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Eight independent variants were suggestively (P-value threshold ≤5×10 ) associated with exacerbations despite LABA use. No strong effects of single nucleotide polymorphisms (SNPs) on exacerbations during LABA use were identified. We identified two loci (TBX3 and EPHA7) that were previously implicated in the response to short-acting beta2-agonists (SABA). These loci merit further investigation in response to LABA and SABA use. No strong effects of single nucleotide polymorphisms (SNPs) on exacerbations during LABA use were identified. W
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