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In this study, we performed a microarray research to analyze the genes up-regulated in PDAC mobile outlines under hypoxia in comparison to normoxia, and identified human being family members with sequence similarity 115, user C (FAM115C) as an applicant gene for further research. Our information showed that FAM115C had been overexpressed in PDAC cell lines under hypoxia, and FAM115C inhibition promoted PDAC cellular migration and invasion in vitro. FAM115C inhibition