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Moreover, the observed higher tumour acidity was significantly correlated with an increased number of lung metastases. The findings of this study indicate that the extracellular acidification is associated with the metastatic potential. The findings of this study indicate that the extracellular acidification is associated with the metastatic potential.Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue