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However, rat in vitro studies would still have utility in the absence of human in vitro data. In vitro rat data provide estimates of dermal absorption that are at least as protective as in vivo rat data, and thus could also be considered adequate for use in establishing DAFs. The comparisons presented support potentially using in vitro data alone for DAF derivation for human health risk assessment of pesticides.Advancement of understanding the etiology and treatment of epilepsy has largely depended on the use of acute and chronic anima
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