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Diabetes diagnosed at 6months of age is usually monogenic. However, 10-15% of affected infants do not have a pathogenic variant in one of the 26 known neonatal diabetes genes. We characterised infants diagnosed at 6months of age without a pathogenic variant to assess whether polygenic type 1 diabetes could arise at early ages. We studied 166 infants diagnosed with type 1 diabetes at 6months of age in whom pathogenic variants in all 26 known genes had been excluded and compared them with infants with monogenic neonatal diabet