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Critical-care ventilators provide patient circuit compensation (CC) to counteract the loss of volume due to patient circuit compliance. No studies show the effect of inspiratory efforts (indicating maximal value of the muscle pressure waveforms [P ]) on CC function. The goal of this study was to determine how P affects volume delivery with or without CC for both volume control continuous mandatory ventilation with set-point targeting scheme (VC-CMVs) and pressure control continuous mandatory ventilation with adaptive targeting scheme (P
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