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Further, Cbfb knockout exerted no obvious effects on osteoblast proliferation. Overall, these results substantiated that Cbfb could promote fibula fracture healing and osteoblast differentiation and thus provided a promising therapeutic target for clinical treatment of fibula fracture. Overall, these results substantiated that Cbfb could promote fibula fracture healing and osteoblast differentiation and thus provided a promising therapeutic target for clinical treatment of fibula fracture. Modular prosthesis fracture, especially distal femoral fracture, is