https://msdc-0160modulator.com..../increased-degree-of
For 100 y, anesthetics were speculated to target cellular membranes, yet no plausible mechanism appeared to explain a membrane effect on ion channels. Here we reveal that inhaled anesthetics (chloroform and isoflurane) trigger TREK-1 through disruption of phospholipase D2 (PLD2) localization to lipid rafts and subsequent creation of signaling lipid phosphatidic acid (PA). Catalytically dead PLD2 robustly obstructs anesthetic TREK-1 currents in whole-cell patch-clamp tr
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