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420 to 100 pg mL-1 with a detection limit of 0.256 pg mL-1. Likewise, a linear regression of the concentration of ox-LDL was obtained over the range from 0.500 pg mL-1 to 60.0 pg mL-1, with a detection limit of 0.330 pg mL-1. This research provides a new method for making a clinical diagnosis and obtaining an early indication of CHD due to the high performance sensing of these two biomarkers. Ever-growing application of engineering nanoparticles in many sectors of the society requires efficient methods to extract them from soil and sed