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Nonetheless, no instance has been reported up to now with C(5) substitutions. Here, we introduce a fluorinated CMP integrating trifluoromethyl groups during the C(5) position of pseudoproline residues. In tripeptide models, our CD, NMR, and molecular dynamics (MD) studies have shown that, when correctly organized, these deposits meet with the structural demands for a triple-helix assembly. Two host-guest CMPs were synthesized and analyzed by CD spectroscopy. The NMR evaluation in answer of the most s