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Finally, we demonstrate that the PB nanoprobe is successfully able to image the variation of ONOO- in drug-induced hepatotoxicity in vivo by PAI and MRI bimodal imaging. Notably, the complementarity of such dual-modality imaging could not only endow our probes with better accuracy and higher penetration depth for visualizing of ONOO- in drug-induced liver injury but also provide anatomical structure to identify the injury area of livers.Copper is an essential element that plays an important role in both cancer development and growth. Ind