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Meanwhile, activation of surface states of CdS quantum dots also led to emission enhancement. Both of the two factors together contributed to the fluorescence enhancement and ultimately to the sensitivity to zinc ion sample detection.MHI-148 is a type of heptamethine cyanine dye that can cross the cytoplasmic membrane of lung cancer cells. Here we tested the cytotoxic, in vivo imaging of MHI-148 in lung-cancer nude mice model. Ex vivo imaging was also been measured by testing the major tissue fluorescence intensity. And, the small molecul