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When comparing antegrade and retrograde methods, there were no differences in baseline data and angiographic or clinical outcomes. Favorable functional outcome was significantly higher in the M2 occlusion group (P=0.011). In multivariate analysis, baseline NIHSS 15, age 80, and M2 occlusion were revealed as independent predictors of favorable outcome. Different endovascular sequences for tandem extracranial cervical carotid and intracranial large vessel occlusion do not affect angiographic or functional outcomes. Intracranial M2