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Two patients (15%) exhibited reduced levels of p53 atomic retention. After a 10-year followup, 7 (54%) regarding the high-grade DM situations had progressed to gastric cancer tumors. These outcomes declare that DM is characterized by telomere shortening, TERT expression, and stem cell expansion, and high-grade DM is a high-grade abdominal metaplasia that likely signifies a precancerous lesion of gastric cancer tumors. High-grade DM is expected to successfully avoid development to gastric cancer