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was highly expressed in CD19 B cells of CLL patients. knockdown induced cell cycle arrest and cell apoptosis, and inhibited , and expression in CLL cells. Taken together, we demonstrated that plays a critical role in cell proliferation and the cell cycle of human CLL cells. knockdown induced cell apoptosis, and reduced , and expression, and may therefore be used as a therapeutic target of CLL. Taken together, we demonstrated that KIAA0101 plays a critical role in cell proliferation and the cell cycle of human CLL cells. KIAA0101 knockd