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The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies that can be based on normal tissue complication probability (NTCP) models. We developed and externally validated NTCP models for common late side-effects following PBT in brain tumour patients to optimise patients' quality of life. Cohorts from three PBT centres (216 patients) were investigated for several physician-rated endpoints at 12 and 24months after PBT alopecia, dry eye syndrome, fatigue, headache, hearing and memory impairme