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LOX, additionally, plays both activity-dependent and separate extracellular, intracellular and nuclear roles that fulfill considerable functions in typical areas, and play a role in vascular, cardiac, pulmonary, dermal, placenta, diaphragm, renal and pelvic floor problems. LOX activities are also recognized in glioblastoma, diabetic neovascularization, osteogenic differentiation, bone matrix formation, ligament remodeling, polycystic ovary problem, fetal membrane layer rupture and tumef