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The study aimed to explore the relationship of different exposure measures with I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, and discuss dosing implications of the results. A population exposure-response analysis was performed using nonlinear mixed-effects modelling. Data from 95 adult patients with benign thyroid disease were analysed. Evaluated exposure parameters were administered radioactivity dose (Aa) [MBq], total absorbed dose (ABD) [Gy], max