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VEGF expression showed an increase in group 2, whereas it decreased in group 3. CONCLUSION The antioxidant G. lucidum is thought to induce angiogenesis by reducing the apoptotic effect in testicular torsion-detorsion.PURPOSE To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DB with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. METHODS Forty-two 5-mm diameter CSDs were made bilaterally