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Second, an efficient method quickly calculates the supports of negative sequences. Our method only uses the information about the corresponding positive sequential patterns (PSPs) and avoids additional database scans. Finally, a novel and efficient algorithm, NegI-NSP, is proposed to efficiently identify highly valuable NSPs. Theoretical analyses, comparisons, and experiments on four synthetic and two real-life data sets clearly show that NegI-NSP can efficiently discover more useful NOBs.The need for medical image encryption is increasi