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in urine may improve the feasibility of therapeutic drug monitoring and personalized dose adjustment in TB endemic settings. Mycobacterium tuberculosis is able to survive and persist as an intracellular pathogen by modulating its own metabolism and host immunity. The molecules and mechanisms utilized to accomplish this modulation are not fully understood. The present study elucidates the effects of M. tuberculosis secretory antigens on T-cell-receptor (TCR)/CD28-triggered signaling in Jurkat T-cells. In the present study, intracellular calcium mobilization