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on of [iMg] was significantly associated with shivering. Colorectal cancer is the second most common cause of cancer death worldwide. Aspirin, due to its antineoplastic effects, has been suggested to have chemopreventive effects on colorectal cancer based on recent trials. We conducted this systematic review and meta-analysis to provide an updated evidence about the long-term efficacy of daily aspirin use in the prevention of colorectal cancer. We searched Medline/PubMed, Ovid, Web of Science, and Cochrane Library. We included randomize