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96 (0.85, 1.07)). The difference increased when removing offspring with genetic/chromosomal defects (mothers OR 1.15 (1.01, 1.32) and fathers 0.93 (0.83, 1.05)). The positive association with maternal pregnancy smoking appeared to be driven by non-severe CHD cases (OR 1.22 (1.04, 1.44)). Associations with maternal (OR 1.16 (0.52, 2.58)) and paternal (OR 1.23 (0.74, 2.06)) moderate/heavy pregnancy alcohol consumption were similar. We found evidence of an intrauterine effect for maternal smoking on offspring CHDs, but no evidence for higher mate